Welcome to PreCancerous Molecular Resource (PCMR)

Even with significant progress in screening and treatment, cancer continues to be a major cause of death worldwide. The formation of cancer encompasses key transitions, starting from normal to precancerous lesions, and advancing to malignant states. These transitions are characterized by abnormal histological and immunohistological features combined with molecular information. Early detection and intervention of precancerous lesions are fundamental to reducing cancer morbidity and mortality, offering a greater chance of complete recovery. It is exemplified by substantial decline in cervical cancer rates following systematic screening and vaccination programs. But most cancers are significantly hindered by the lack of available dynamic liquid biopsy markers in precancerous conditions, and knowledge about key events that trigger normal tissue to enter a premalignant state and drive premalignant lesions to invasive carcinoma.

PCMR hosts comprehensive resources on precancerous lesions and offers user-friendly tools to investigate precancerous lesions. As research progresses, PCMR will expand to encompass more abundant omics data on precancerous lesions from various organ and tissue types, along with precancer-related genes from a wider range of cancers, aiding worldwide researches in early cancer diagnosis and intervention.