Welcome to Human Ocular Single-Cell Atlas (HOSCA)
The human eye is a highly specialized organ composed of diverse tissues, each with unique cellular microenvironments that are crucial for vision. Recent advancements in single-cell RNA sequencing (scRNA-seq) have provided unprecedented opportunities to explore the cellular heterogeneity of ocular tissues and diseases. Human Ocular Single-Cell Atlas (HOSCA) is an atlas-scale curated database that integrates and harmonizes over 3.88 million single-cell transcriptomic profiles spanning 16 ocular anatomical regions and 15 associated diseases from 704 human samples and 60 high-quality scRNA-seq datasets. As the largest ocular single-cell resource to date, HOSCA bridges the gap between atlas-scale data and precision ophthalmology and provides a powerful platform for advancing our understanding of ocular biology and diseases.
Anatomy of Eye
- Uvea
- Choroid
- Ciliary body
- Iris
- Lens
- Cornea
- Aqueous humor
- Trabecular meshwork
- Lacrimal gland
- Whole eye
- Lacrimal sac
- Retinal pigment epithelium
- Retina
- Optic nerve
- Sclera
- Conjunctiva
UMAP visualization of annotated cell populations via anatomy
The uvea contains 4 datasets with 24 samples and a total of 131,866 cells.
The choroid contains 6 datasets with 83 samples and a total of 189,928 cells.
The ciliary body contains 3 datasets with 9 samples and a total of 74,269 cells.
The iris contains 3 datasets with 18 samples and a total of 69,281 cell.
The lens contains 1 datasets with 3 samples and a total of 13,289 cells.
The cornea contains 10 datasets with 76 samples and a total of 368,952 cells.
The aqueous humor contains 2 datasets with 30 samples and a total of 48,189 cells.
The trabecular meshwork contains 2 datasets with 12 samples and a total of 50,246 cells.
The lacrimal gland contains 1 datasets with 5 samples and a total of 1,408 cells.
The whole eye contains 2 datasets with 19 samples and a total of 130,278 cells.
The lacrimal sac contains 1 datasets with 5 samples and a total of 26,484 cells.
The retinal pigment epithelium contains 3 datasets with 32 samples and a total of 49,370 cells.
The retina contains 32 datasets with 327 samples and a total of 2,536,032 cells.
The optic nerve contains 1 datasets with 21 samples and a total of 93,374 cells.
The sclera contains 1 datasets with 1 samples and a total of 843 cells.
The conjunctiva contains 1 datasets with 10 samples and a total of 46,205 cells.
Summary
Statistics
- Number of Anatomies: 16
- Number of Datasets: 60
- Number of Samples: 704
- Number of Cells: 3,884,903
- Release Date: Jan. 2025
- Version: v1.00